Webinar: Novel HPMC Capsules – Bioequivalence & Functional Performance

Hydroxypropyl methylcellulose (HPMC) capsules are well-vetted and have been used in pharmaceutical formulations for many years. But a new HPMC-polymer capsule (Vcaps® Plus) made through an innovative thermo-gelation process avoids the addition of gelling agents that can react with the pH or ionic strengths of dissolution media, providing gelatin-like performance. 

Although HPMC capsules are used in marketed drugs, there are few comparisons of the in-vivo performance between gelatin and HPMC in literature. In this webinar, experts will present the in-vitro dissolution and an in-vivo bioequivalence study comparing the performance of the identical formulation of three different drugs in Vcaps Plus HPMC capsules to hard gelatin capsules. 

In addition, we will present data suggesting there may be value in formulating with HPMC in order to increase bioavailability of weakly-basic drugs and of high energy forms of low solubility drugs, such as salts and amorphous solid dispersions (ASDs), by sustaining drug supersaturation in the intestine.