Pfizer surprises ATTR rivals with tafamidis success

Shares in Alnylam and Ionis fell sharply after Pfizer said its experimental drug improved outcomes among certain ATTR patients in a late-stage study.

By Ned Pagliarulo • April 2, 2018

Redx study on hold before getting off the ground

A Phase 1/2a study has been halted for unspecified safety signals after dosing of the first patient.

By Suzanne Elvidge • April 2, 2018

Explore the Trendline➔

Neuroscience drug development

Enthusiasm is running higher among drugmakers and investors for neuroscience drug development, buoyed by recent approvals of new Alzheimer’s, ALS and depression medicines.

By BioPharma Dive staff

Tesaro posts mixed Phase 2 data for Zejula combo

New trial results suggest Zejula and a PD-1 blocker may provide "meaningful clinical benefit," the biotech said. Some analysts didn't have such a rosy outlook, however.

By Randi Hernandez • March 28, 2018

Roche reports deaths of patients taking Hemlibra

The Swiss pharma said the recent patient deaths were judged unrelated to treatment, but the update stirred safety concerns for the newly approved drug.

By Ned Pagliarulo • March 28, 2018

Esperion bolsters cholesterol drug with new combo data

A mid-stage study showed adding Esperion's bempedoic acid to background treatment with PCSK9 inhibition delivered further LDL cholesterol lowering. 

By Suzanne Elvidge • March 28, 2018

Verona touts potential of mid-stage COPD drug

Jefferies called the drug a potential blockbuster and noted that, with strong Phase 2 data in hand, Verona would have a "compelling out-licensing opportunity in 2-3 years' time."

By Randi Hernandez • March 27, 2018

AnaptysBio's new allergy data has investors scratching their heads

A decision to exclude four patients with mild baseline symptoms from an interim analysis muddied otherwise positive results for its anti-inflammation drug.

By Jacob Bell • March 27, 2018

Protagonist halts colitis study after missed endpoint

Shares in the biotech plunged after the failure of its ulcerative colitis drug in Phase 2b study.

By Suzanne Elvidge • March 27, 2018

In push to use pot for pain, synthetics hold upper hand

The first plant-derived cannabinoid drug faces an FDA advisory panel meeting in April. If approved, it could swing the door to the cannabis market wide open.

By Randi Hernandez • March 26, 2018

Lilly's bet on pain stands out amid bare pharma pipeline

Even as the opioid epidemic has heightened the need for non-addictive painkillers, few pharma companies have made pain a therapeutic area of focus.

By Ned Pagliarulo • March 26, 2018

Biohaven falls on weak migraine data

The highly anticipated CGRP data disappointed investors, sending shares in the Connecticut biotech tumbling downward. 

By Lisa LaMotta • March 26, 2018

Ablynx's anti-inflammation drug fails in lupus

Vobarilizumab missed the primary endpoint of the mid-stage STEADY study, painting a gloomier outlook for Ablynx's opt-in deal with AbbVie.

By Jacob Bell • March 26, 2018

Roche's momentum grows as Tecentriq combo delivers survival benefit

Combining Tecentriq with Avastin plus chemo helped advanced lung cancer patients live longer, a result that could help Roche compete with class rivals.

By Ned Pagliarulo • March 26, 2018

Prescribed Reading: AbbVie disappoints; Regeneron deals in genes

Investors questioned AbbVie's strategy in oncology after a clinical miss. Elsewhere, Regeneron partnered with Alnylam to probe the potential of a genetic discovery.

By Lisa LaMotta • March 23, 2018

Novartis readies MS drug for speedy US filing

If approved, siponimod would become the first disease-modifiying treatment for secondary progressive MS, a later-onset form of the debilitating condition.

By Ned Pagliarulo • March 22, 2018

AbbVie oncology push in question after Rova-T disappoints

Results from the Phase 2 TRINITY study did not live up to AbbVie's — and investors' — expectations, casting a shadow on a major acquisition.

By Lisa LaMotta • March 22, 2018

Brain Talk: How new approaches to clinical trials benefit mental health research

Every day, new research opens doors to the brain's inner workings. The first in this Brain Talk series zeroes in on brain research today for depression and bipolar disorders.

March 21, 2018

Zealand's rescue pen for hypoglycemia hits in Phase 3

Dasiglucagon showed positive results in the first of multiple late-stage studies.

By Suzanne Elvidge • March 21, 2018

Eylea positive in diabetic retinopathy, but analysts skeptical

Regeneron's blockbuster showed favorable results, but there's debate about how incremental the new indication could be for the drug. 

By Lisa LaMotta • March 20, 2018

Tecentriq combo success boosts Roche in lung cancer

Positive results from the Phase 3 IMpower 131 study could hand Roche an advantage in the first-line treatment setting for squamous NSCLC.

By Ned Pagliarulo • March 20, 2018

Arena keeps up comeback with positive UC data

The biotech is clawing its way back from obscurity as it produces a second round of positive clinical results. 

By Suzanne Elvidge • March 20, 2018

Novo takes aim at obesity with positive semaglutide results

The Danish drugmaker announced positive Phase 2 results for once-daily injectable semaglutide in obese patients without diabetes.

By Lisa LaMotta • March 19, 2018

Heron's non-opioid pain drug succeeds in Phase 3, lifting shares

Treatment with HTX-011 following surgery reduced both pain intensity and need for opioids — results Heron hopes can secure a broad label from the FDA.

By Ned Pagliarulo • March 19, 2018

Prescribed Reading: Neuro's comeback tour

Activity in the neuroscience space spiked higher, with a flurry of licensing deals highlighting BioPharma Dive's prediction the field is ready for a resurgence.

By Lisa LaMotta • March 16, 2018

Solid Biosciences reveals upgraded clinical hold for gene therapy

The newly public biotech lost more than 60% of its value after announcing an FDA hold for its DMD study. 

By Lisa LaMotta • March 15, 2018