Deep Dive: Page 3
Industry insights from our journalists
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                'This is the time to double down': Top Vertex executives defend research plan as pressure buildsA series of setbacks has led to criticism of the storied biotech's bid to diversify. But Vertex intends to stay the course, its CEO and top scientist say. Ben Fidler • Sept. 22, 2021
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                Biotech’s M&A outlook is uncertain. Track the deals that are happening here.Novartis' acquisition of Avidity Biosciences is the year’s second-largest by total consideration, trailing only Johnson & Johnson’s $14.6 billion buyout of Intra-Cellular Therapies in January. Ned Pagliarulo, Jacob Bell and Julia Himmel • Updated Oct. 24, 2025
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                   del Aguila III, Ernesto. (2018). "CRISPR Cas9" [Illustration]. Retrieved from Flickr. del Aguila III, Ernesto. (2018). "CRISPR Cas9" [Illustration]. Retrieved from Flickr.  Intellia, with first results, delivers a 'landmark' for CRISPR gene editingResults published in The New England Journal of Medicine offer the first clinical evidence that CRISPR gene editing inside the body can be safe and effective, a culmination of years of scientific research. Ben Fidler • June 26, 2021
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                8 key clinical trials to watch for the rest of 2021The next six months could feature clinical milestones for CRISPR gene editing, the treatment of COVID-19 and gene-targeted cancer therapy. Ben Fidler • June 21, 2021
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                'The lights are no longer green': Antitrust regulators reassess pharma dealsThe FTC and its counterparts abroad are rethinking their approach to drugmaker acquisitions. Past scrutiny offers clues to where they may look next. Jonathan Gardner • June 10, 2021
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                A first-of-its-kind Alzheimer's drug raises heavy questions around who will and won't get itBiogen priced its newly approved medicine Aduhelm at an average cost of $56,000 a year, adding affordability to other barriers patients may face. Jacob Bell • June 8, 2021
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                In historic move, FDA approves a closely watched and controversial Alzheimer's drugThe decision cleared the way for what many predicted would become a lucrative treatment. But a high price and controversy over whether Biogen's Aduhelm benefits patients weighed heavily on the drug's launch. Jacob Bell • Updated June 7, 2021
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                Trump tax law cut what US drugmakers owed. Now they fear an increase.The 2017 law saved pharmaceutical companies billions of dollars, BioPharma Dive found. Executives are now fiercely opposing tax hikes proposed by President Biden, claiming they've since boosted domestic investment. Jonathan Gardner • May 17, 2021
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                How Gilead finally spent its moneyThis year, the biotech spent about $27 billion trying to become a leader in cancer research. Executives who spoke to BioPharma Dive said there's still work to be done. Jacob Bell • Nov. 24, 2020
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                Biotech IPOs are the industry’s lifeblood. Track how they’re performing.MapLight Therapeutics priced a $251 million IPO on Sunday with the help of a little-used regulatory workaround enabling it to go public during a federal government shutdown. Ben Fidler and Gwendolyn Wu • Updated Oct. 26, 2025
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                From no drugs to 3: Patients with spinal muscular atrophy now face hard choicesThe availability of three vastly different, cutting-edge medicines for the rare disease has put patients, families and doctors in an unfamiliar position. Jonathan Gardner • Oct. 5, 2020
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                How biotech and pharma companies pay their CEOs, and their workersThe median CEO of 231 drug companies analyzed by BioPharma Dive earned 50% more last year than in 2017, a leap that far outpaced the more modest pay gains among employees. Ned Pagliarulo • Sept. 9, 2020
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                Relay Therapeutics set out to change how drugs are designed. Can it continue what Vertex began?Vertex pioneered a more precise way of developing drugs. Relay, which has raised nearly $1 billion since its founding, thinks it can go one step further. Ned Pagliarulo • Aug. 24, 2020
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                A cure for hemophilia seemed closer than ever. For many patients, it’s now further out of reachThe surprise rejection of BioMarin's hemophilia A gene therapy delayed a decades-long mission to fix the rare bleeding disorder. Jacob Bell • Updated Aug. 19, 2020
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                Vaccines can end the coronavirus pandemic. Will every country get them?Scientists around the world are racing to develop a coronavirus vaccine. But the factories slated to make the leading candidates are concentrated in a handful of countries, raising concerns about global access. Jonathan Gardner • June 23, 2020
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                Coronavirus vaccines are rolling out quickly. Here's where the pipeline stands.Fuller data in hand, Pfizer and BioNTech plan to soon seek full U.S. approval for their vaccine in 12- to 15-year-olds. Ned Pagliarulo, Jonathan Gardner, Shoshana Dubnow, Ben Fidler and Nami Sumida • Updated Nov. 24, 2021
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                Venture capital found its footing in biotech. Then came the virus.There's been no better time for venture firms to invest in drug startups than the past few years. But when a virus upended the world, it raised new questions about what types of investors and investments would succeed moving forward. Jacob Bell • May 26, 2020
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                   National Institute of Allergy and Infectious Diseases. (2020). "Novel coronavirus SARS-CoV-2" [Microscope image]. Retrieved from https://www.flickr.com/photos/nihgov/49565158908/in/album-72157713108522106/. National Institute of Allergy and Infectious Diseases. (2020). "Novel coronavirus SARS-CoV-2" [Microscope image]. Retrieved from https://www.flickr.com/photos/nihgov/49565158908/in/album-72157713108522106/.  A closer look at the race to develop antibody drugs for COVID-19Eli Lilly, Regeneron and China's Junshi are now testing antibody drugs in clinical trials, while others are close behind. Here's why they will matter. Ben Fidler • May 12, 2020
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                A coronavirus vaccine may arrive next year. 'Herd immunity' will take longer.Experimental vaccines for COVID-19 are moving at an unprecedented pace. But that could mean researchers won't definitively know whether they're safe and effective when they do arrive. Jonathan Gardner • May 4, 2020
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                Big pharma shied away from gene therapy for years. Academia picked up the slackThe byproduct was richer licensing fees for universities and a throng of startups, but also questions on fair prices and research priorities. Jonathan Gardner • March 17, 2020
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                Big pharma backed away from brain drugs. Is a return in sight?Biotech executives see a new era of neuroscience breakthroughs on the horizon. But in a historically challenging space, it's hard to pinpoint what would cause big pharma to dive back in — and what ripples that would create. Jacob Bell • Jan. 29, 2020
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                Will sky-high drug prices spur the US to use an obscure power over patents?New cell therapies as well as gene-based treatments like Zolgensma benefited from NIH funding of early-stage research. Advocates say the time is now for the government to invoke its "march-in" rights. Jonathan Gardner • Dec. 4, 2019
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                Bankrupt biopharmas are rare. 2019 has some worried that's changing.Eleven biopharmas declared bankruptcy in 2019, more than any other year since at least 2011. Rising market pressures, coupled with legal liabilities, risk more companies falling to zero, experts warn. Andrew Dunn • Nov. 19, 2019
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                31 biopharmas at high risk of bankruptcy in 2020BioPharma Dive dug into data from a credit monitoring firm to identify drugmakers at high risk of going bankrupt, including companies like Teva, Bausch Health and Novavax. Andrew Dunn • Nov. 19, 2019
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                The running list of 2019 biopharma bankruptciesFrom antibiotic developers like Achaogen to opioid drugmakers like Purdue and Insys, 2019 saw an uptick in biopharmas filing for Chapter 11. Andrew Dunn • Nov. 19, 2019
 
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
     
    
        
    