Clinical Trials: Page 14
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ESMO24: A cancer cachexia drug, VEGF enthusiasm and immunotherapy’s survival impact
Results for Pfizer’s ponsegromab looked promising, while BioNTech and Instil Bio capitalized on momentum surrounding a kind of bispecific antibody.
By Ned Pagliarulo , Jonathan Gardner • Sept. 16, 2024 -
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As Biosecure bill advances, drugmakers prepare for prospect of China pivot
While companies’ exposure to the Biosecure Act varies, drugmakers are bracing for the knock-on effects that its passage could create in the market for contract services.
By Amy Baxter • Sept. 16, 2024 -
Explore the Trendline➔
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TrendlineNeuroscience drug development
Enthusiasm is running higher among drugmakers and investors for neuroscience drug development, buoyed by recent approvals of new Alzheimer’s, ALS and depression medicines.
By BioPharma Dive staff -
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Sponsored by Worldwide Clinical TrialsAccelerating the new wave of CAR T therapy trials
Applying CAR T-cell therapy in new clinical settings presents unique challenges. Worldwide Clinical Trials is at the forefront, partnering with drug development teams to map this new path forward.
Sept. 16, 2024 -
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Sponsored by FortreaBridging science and humanity: How systems thinking should shape clinical trial execution
Applying a systems thinking approach can create improvements in scientific integrity, operational feasibility and scalability.
By Tetyana Korchak, MD - Global Lead & Executive Director, Strategic Delivery & Growth, at Fortrea • Sept. 16, 2024 -
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Ten-year survival data show long-term benefit of immunotherapy in melanoma
“It’s a real opportunity to reinforce hope and to start getting comfortable with the word ‘cure,” said a leader of the study, which tested Opdivo and Yervoy.
By Jonathan Gardner • Sept. 15, 2024 -
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TIGIT drug from iTeos shrinks lung tumors in trial
Results presented at ESMO showed tumor response rates that matched the bar set by analysts for success. But they may not yet be enough to dispel doubts around TIGIT as a target.
By Ned Pagliarulo • Sept. 14, 2024 -
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Fulcrum shares collapse as Sanofi-partnered muscular dystrophy drug fails key test
The biotech will now suspend development of a drug prospect that Sanofi acquired partial rights to just four months ago.
By Jonathan Gardner • Sept. 12, 2024 -
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Dupixent succeeds in chronic hives study, giving Sanofi, Regeneron a chance to rebound
Following an FDA rejection last year, the partners plan to resubmit their application for approval of Dupixent in chronic spontaneous urticaria.
By Kristin Jensen • Sept. 11, 2024 -
Permission granted by Centessa Pharmaceuticals
Investors are waking up to Centessa’s sleepiness drug
A small, early study produced what one analyst called “highly compelling” results that lifted the company’s shares by as much as 15% Tuesday.
By Jacob Bell • Sept. 10, 2024 -
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New data add to doubts about AstraZeneca, Daiichi’s Enhertu successor
The partners’ ADC didn’t significantly extend survival in lung cancer patients who were expected to benefit the most from treatment in a Phase 3 trial.
By Ben Fidler • Sept. 10, 2024 -
Permission granted by Relay Therapeutics
Relay breast cancer drug shows potential in early trial
Results from a small study suggest Relay's drug could avoid some of the toxicity associated with existing PI3Ka inhibitors like Novartis' Piqray.
By Ned Pagliarulo • Sept. 9, 2024 -
shutterstock.com/Juan Gaertner
Early study data puts Terns among obesity drug contenders
A once-daily pill the biotech is developing helped some people with obesity lose more than 5% of their weight in a month, spurring a stock bump and plans to bring the drug into further testing.
By Jonathan Gardner • Sept. 9, 2024 -
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Summit lung cancer drug shows ‘striking’ benefit over Keytruda
Detailed study results backed up Summit's claim that its drug "decisively beat" Merck's dominant immunotherapy in a first-of-its-kind finding.
By Ben Fidler • Updated Sept. 8, 2024 -
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GSK antibody drug reduces COPD attacks in trial
New trial results could offer support for an expansion of Nucala’s label after U.S. regulators rejected GSK’s submission in 2018.
By Kristin Jensen • Sept. 6, 2024 -
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Lilly builds case for weekly insulin shot
New data show Lilly’s longer-lasting insulin matched daily shots in controlling blood sugar, adding to positive findings the company disclosed in May.
By Jonathan Gardner • Sept. 5, 2024 -
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Deep DiveA decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology
Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.
By Jonathan Gardner • Sept. 4, 2024 -
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Vaxcyte’s “best-case” data for pneumococcal vaccine boost shares
The company's value jumped by several billion dollars as trial results showed its experimental shot could match and, in some cases, even outperform Pfizer's market-leading Prevnar 20.
By Delilah Alvarado • Sept. 3, 2024 -
Permission granted by Recursion Pharmaceuticals
AI specialist Recursion says lead drug is safe, but efficacy less clear
The Phase 2 results for Recursion’s treatment are the first in a series of important trial readouts for the high-profile “techbio” company.
By Ned Pagliarulo • Sept. 3, 2024 -
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Sanofi finds a silver lining in mixed MS drug results
Tolebrutinib, which Sanofi acquired in a $3.7 billion deal, failed two studies in people with relapsing disease, but succeeded in a type of multiple sclerosis that has no approved therapies.
By Ben Fidler • Sept. 3, 2024 -
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Full study data back Alnylam heart drug’s benefit, but leave doctors with tough choices
Shares of Alnylam fell as much as 9% amid skepticism vutrisiran hasn’t clearly shown it’s superior to other medicines for ATTR cardiomyopathy.
By Ben Fidler • Aug. 30, 2024 -
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Keytruda fails lung and skin cancer trials, limiting further expansion
The trial setbacks for Merck’s best-selling drug, which faces patent expiration in 2028, are a blow to the company’s plans for further indication expansion.
By Jonathan Gardner • Aug. 29, 2024 -
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Neurocrine’s mixed schizophrenia data disappoint Wall Street
Despite “positive” results, shares of the biotech slid by 20%. Analysts cautioned that Neurocrine shouldn’t get “the benefit of the doubt” with its data.
By Jacob Bell • Aug. 28, 2024 -
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After an FDA rejection, here’s what’s next in the psychedelics pipeline
By rejecting the first MDMA therapy this month, the FDA signaled to the psychedelic drug field that the road to approval isn’t easy.
By Amy Baxter • Aug. 28, 2024 -
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Sponsored by Worldwide Clinical TrialsRadiopharmaceutical trials: The critical role of site selection and support
Through effective collaboration, partnerships can accelerate the development of lifesaving therapies and improve patient outcomes.
Aug. 26, 2024 -
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Avidity, Kymera raise fresh funds; Walgreens partners with BARDA
Avidity raised $345 million to advance development of RNA medicines designed to combine the advantages of oligonucleotides and antibodies.
By BioPharma Dive staff • Aug. 20, 2024
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