- Johnson & Johnson has selected a lead vaccine candidate for the novel coronavirus and expects to start testing it in humans by September at the latest. That means J&J could disclose data before the end of the year, which then may allow the vaccine to be available for emergency use in early 2021, according to the pharma giant.
- Relatedly, J&J also announced Monday an expanded partnership with the Biomedical Advanced Research and Development Authority, or BARDA. The parties have agreed to spend more than $1 billion to co-fund vaccine research, development and clinical testing.
- Additionally, J&J said it will scale up its global vaccine manufacturing capacity so that more than a billion doses of a vaccine can be made. The company intends to soon start producing the vaccine "at risk," and is "committed to bringing an affordable vaccine to the public on a not-for-profit basis for emergency pandemic use."
J&J was the earliest big pharma to announce plans for developing a vaccine against the novel coronavirus, which causes the sometimes deadly respiratory illness COVID-19. J&J says it collaborated with academic institutions to produce what's now J&J's lead vaccine, as well as two back-up candidates.
Like other companies working on novel coronavirus vaccines, J&J is trying to speed up development. Vaccines typically take years to make and validate via testing, but the threats posed by a global pandemic are pushing drugmakers to move quicker.
Timelines for novel coronavirus vaccines
|Drugmaker||Vaccine type||Human testing began/expected to begin|
|CanSino Biologics||Viral vector||March 2020|
|Pfizer/BioNTech||mRNA||By end of April 2020|
|CureVac||mRNA||Early summer 2020|
|J&J||Viral vector||By September 2020|
|Sanofi||Protein-based||By end of 2020|
|Sanofi/Translate Bio||mRNA||By end of 2020|
SOURCE: Company releases
BARDA is helping finance J&J's vaccine work through an expanded agreement in which the agency funds development through Phase 1. After that early testing, BARDA can decide whether to invest more.
Along with vaccine work, J&J and BARDA have been screening libraries of chemical compounds in search of antivirals that could be used to treat this new virus. The libraries include J&J's own, as well as those of other pharmaceutical companies. Notably, J&J has an infectious disease business that brings in more than $3 billion a year, most of which comes from five marketed antivirals used to treat HIV.
Antivirals, such as Gilead's remdesivir, have garnered much attention as possible treatments for COVID-19. Yet there are other drug types under investigation too — Regeneron, Eli Lilly and Biogen, for example, are each investigating experimental antibodies.