Gene Therapy: Page 17
-
Getty / Edited by BioPharma Dive
After setbacks, a gene therapy company mulls a sale
Sio Gene Therapies, formerly known as Axovant, said it's focused on conserving cash, and has decided to significantly reduce its workforce and terminate licensing agreements on its last two pipeline programs.
By Jacob Bell • April 28, 2022 -
FDA clears Pfizer to restart Duchenne gene therapy trial, with new safeguards
The regulator has asked Pfizer to closely monitor patients in a hospital setting for a week as part of a deal to end a study suspension that's lasted more than four months.
By Ben Fidler • April 28, 2022 -
Explore the Trendline➔
Getty Images
TrendlineGene Therapy
Rapid scientific advances have put the gene therapy field at the forefront of biomedical research. But, as recent setbacks have shown, researchers and drugmakers still face major challenges.
By BioPharma Dive staff -
Getty Images
Solid Bio joins slate of biotech layoffs, shedding 35% of its workforce
The company is the latest in a growing list of gene therapy developers to restructure and cut jobs during an industry-wide downturn.
By Jonathan Gardner • April 27, 2022 -
Getty Images
Undeterred by gene therapy's struggles, a startup launches into a downturn
Apertura Gene Therapy, a new company formed by Deerfield, is hoping a suite of next-generation tools will help it stand out at a time when this area of research has fallen out of favor with some public investors.
By Jacob Bell • April 26, 2022 -
National Institutes of Allergy and Infectious Diseases. (2016). "Human natural killer cell" [Micrograph]. Retrieved from Flickr.
Nkarta gives first look at two 'natural killer' cell therapies for blood cancer
The results build on early evidence that NK cell treatments may become viable medicines for leukemia and lymphoma, while it's still unclear whether they're as effective, or last as long, as T cell therapies.
By Ben Fidler • April 25, 2022 -
Getty / Edited by BioPharma Dive
Regeneron, in search of an eye gene therapy, turns to a young biotech
Facing mounting competition to its top-selling drug Eylea, Regeneron is teaming up with ViGeneron to develop a genetic medicine for an inherited retinal disease.
By Jacob Bell • April 6, 2022 -
FDA clears second Novartis plant for gene therapy manufacturing
The 170,000-square-foot plant located in North Carolina can now fulfill its primary function: producing commercial-grade Zolgensma, which has become one of the Swiss pharma's top-selling drugs.
By Jacob Bell • April 5, 2022 -
Bluebird, after warning of dwindling cash, to lay off 30% of workforce
The restructuring will result in job cuts across the company, a spokesperson said, as Bluebird awaits regulatory decisions on two of its products.
By Ben Fidler • April 5, 2022 -
Pogonici/Stock.adobe.com
Sponsored by SGSViral vector design for gene therapies
Safety issues in clinical trials cast doubt on the ability of gene therapy to safely mitigate disease, prompting further research into understanding the virus-host interaction that resulted in new generations of viral vectors.
By Robert Cartee, Ph.D., Senior Director Biopharmaceutical Services • April 4, 2022 -
Getty / Edited by BioPharma Dive
Yet another gene therapy developer turns to layoffs
Taysha Gene Therapies is narrowing its research efforts and cutting around 35% of its workforce, the latest in a series of layoffs announced by makers of genetic medicines.
By Jacob Bell • April 1, 2022 -
Permission granted by Biogen
Biogen shelves ALS drug after early-stage trial failure
The study setback raises questions over how well a type of genetic medicine can work in adults with central nervous system disorders like ALS.
By Jonathan Gardner • March 28, 2022 -
Getty Images
As biotech retreats, gene therapy companies retrench and redraw plans
At least nine biotechs working in cell or gene therapy have announced layoffs, cost cuts or restructured their research since December — restructurings that have coincided with a stock market downturn.
By Ned Pagliarulo • March 24, 2022 -
Courtesy of Business Wire
Al Sandrock takes on CEO role at gene therapy developer
The well-known researcher and Biogen alumnus has agreed to take the top spot at Voyager Therapeutics, which, last spring, underwent a "strategic shift" that saw its then-CEO and research head depart.
By Jacob Bell • March 22, 2022 -
Courtesy of Scribe Therapeutics
CRISPR pioneer's biotech taps ex-Barclays banker as CFO
In an interview, David Parrot walked through some of the challenges he faces preparing gene editing biotech Scribe Therapeutics for an IPO during a sector-wide downturn.
By Maura Webber Sadovi • March 21, 2022 -
Getty / Edited by BioPharma Dive
FDA sets out advice to developers of gene editing medicines
Draft recommendations from the agency were generally straightforward, analysts said, although the document emphasized the potential safety risks of gene editing.
By Ned Pagliarulo • March 16, 2022 -
Passage Bio to cut jobs in latest biotech restructuring
Stung by a stock market downturn, a number of biotechs are trimming spending and reprioritizing research to save cash. Passage's layoffs will reduce its workforce by 13%.
By Ned Pagliarulo • March 15, 2022 -
Novartis turns cell therapy skill into contract manufacturing deal
In an unusual arrangement, the Swiss pharma will make Carisma Therapeutics' experimental cell therapy at its Morris Plains factory, part of its plans to build up a CMO business.
By Ned Pagliarulo • March 10, 2022 -
Getty / Edited by BioPharma Dive
Novartis turns to Voyager for nervous system gene therapies
The deal, which carries a $54 million upfront payment, could give Novartis access to as many as five of Voyager's capsids, which would be used to develop gene therapies for the central nervous system.
By Jacob Bell • March 8, 2022 -
Getty Images
Gene editing biotechs face new uncertainty after CRISPR patent ruling
A federal patent board ruled Broad Institute scientists were first to a key gene editing advance, weakening the patent position of Intellia and CRISPR Therapeutics, which hold licenses through the University of California.
By Jonathan Gardner • March 2, 2022 -
Permission granted by Intellia Therapeutics
Intellia presses forward with new results for pioneering CRISPR drug
The findings build on early evidence that gene editing inside the body could safely and effectively treat disease, and suggest the effects of Intellia's medicine might last.
By Ben Fidler • Updated Feb. 28, 2022 -
Amicus' SPAC deal unravels, leading to layoffs and cost cuts
The biotech is calling off plans to spin out its gene therapy business via a merger with a blank check company, citing unfavorable market conditions and a "challenging environment."
By Kristin Jensen • Feb. 24, 2022 -
Getty Images
Allogene, slipping in 'off-the-shelf' CAR-T race, prepares for key trials
Allogene, once the clear leader in development of a more convenient option to personalized cancer cell therapies, now is competing with CRISPR Therapeutics and other fast-emerging rivals.
By Ben Fidler • Feb. 24, 2022 -
Permission granted by Spark Therapeutics
Spark CEO Marrazzo, who led company to historic gene therapy approval, to step down
Jeffrey Marrazzo has led Spark since its founding in 2013, through the historic FDA approval of Luxturna and the company's $4.3 billion buyout by Roche.
By Ned Pagliarulo • Feb. 23, 2022 -
Getty Images
BioMarin says gene therapy hold will endure as FDA questions cancer risk
According to BioMarin, the regulator has requested additional data to assess the "theoretical" cancer risk to the treatment, information that will take several quarters to collect.
By Ned Pagliarulo • Feb. 18, 2022 -
National Institutes of Allergy and Infectious Diseases. (2016). "Human natural killer cell" [Micrograph]. Retrieved from Flickr.
Intellia follows CRISPR peers with deal to explore 'natural killer' cell therapy
By partnering with ONK Therapeutics, Intellia joins CRISPR Therapeutics and Editas Medicine in striking deals that marry gene editing with a fast-emerging form of cancer immunotherapy.
By Ben Fidler • Feb. 15, 2022
Previous
